(4-Nitrophenyl)methanesulfonamide → 1-(4-Aminophenyl)methanesulfonamide

Participants

Reaction Steps

A suspension of 4-nitrobenzenemethanesulphonamide (7.11 g) and 5% palladium oxide on charcoal (1.4 g) in ethanol (1.1 l) was hydrogenated at room temperature and pressure. The reaction was terminated after 2.5 l of hydrogen had been absorbed and the catalyst was removed by filtration. The filtrate was concentrated to give the title compoun as a solid (4.72 g). Recrystallisation of a sample from ethanol gave analytically pure material m.p. 166° (bubbles).

Provenance & Evidence