5-bromo-1,1-dimethoxypentane → 2-(5,5-Dimethoxypentyl)-1H-isoindole-1,3(2H)-dione

Participants

Reaction Steps

A mixture of potassium phthalimide (0.48 g) and 5-bromopentanal dimethyl acetal (0.50 g) in dry dimethylformamide (3 ml) was stirred at 90° for 5 h and then allowed to cool. The resultant yellow suspension was then partitioned between water (30 ml) and ethyl acetate (3×30 ml). The combined organic extracts were then dried (Na2SO4) and concentrated in vauco.

Provenance & Evidence