Methyl iodide → HCID 21268843, compound

Participants

Reaction Steps

A mixture of 2.5 g of N,N-dipropyl-5,6-dihydro-4H-thieno[2,3-b]-thiopyran-5-amine in 40 ml of tetrahydrofuran is treated with 4 ml of 2.5 M n-butyl lithium in hexane at 0°. After 30 minutes at 0°, 1.5 g of methyl iodide is added and the mixture is kept at room temperature for 1 hour. Dilution with ether and washing with water followed by drying and removal of the solvent in vacuo affords 2-methyl-N,N-dipropyl-5,6-dihydro-4H-thieno[2,3-b]-thiopyran-5-amine.

Provenance & Evidence