HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → Iso Ganciclovir
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | HCID 135738512 | HCID 135738512 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Methylamine | HCID 6329 | — |
| Product | Iso Ganciclovir | HCID 135446919 | 89.7% |
Reaction Steps
A solution of 1.14 g (3.0 mmole) of 2-acetamide-9-(2,3-diacetoxy-1-propoxymethyl)hypoxanthine (VIII) from Step B above was heated at reflux in 40% aqueous methylamine with stirring under N2 for 1 hour and then cooled. TLC (80:20:2 CHCl3 --CH3OH--H2O) showed complete conversion to the title compound (I). The light orange solution was treated with some charcoal and filtered through Super-Cel. Concentration of the filtrate gave a solid which was recrystallized from H2O (adjusted to about pH 6 with a few drops of CH3COOH) to yield 687 mg of cream-colored crystals, mp 246°-247° dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04816447 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-096886c145554d4697b9551ccfcaefd8 |
| Source note | uspto-grants-1989_03 |