Pyridine → HCID 136085154, compound

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Reaction Steps

A mixture of 5.34 g (20 mmole) of hydrate 9-(2,3-dihydroxy-1-propoxymethyl)guanine, 40 ml of acetic anhydride (increased to 100 ml after several days), 40 ml of pyridine (increased to 80 ml after a few days) and 160 ml of dimethylformamide was stirred at room temperature under a drying tube for a total of 20 days and then concentrated in vacuo. The residue was triturated with 30 ml of methylene chloride and diluted with 100 ml of ether. The solid was collected on a filter, washed with ether, and recrystallized from dioxane-acetic acid to give (after washing with acetone and drying) 4.18 g (62%) of slightly off-white powder, mp 222.5° to 224° C. Structure and purity were confirmed by NMR and TLC (9:1CHCl3 --MeOH).

Provenance & Evidence