Hydrochloric Acid → HCID 21268852, compound

Participants

Reaction Steps

A mixture of 1.3 g of 2-chloro-8-fluoro-3-hydroxy-9-oxo-9H-xanthene, 1.7 g of postassium carbonate, 2.1 g of ethyl bromoacetate and 30 ml of DMF was stirred at 60°-65° C. for 3 hours. After cooling the mixture, 2 g of sodium hydroxide and 100 ml of water were added and the resulting mixture was stirred at 90°-100° C. for 30 minutes. After cooling, the mixture was rendered acidic with hydrochloric acid and the solid crystal was recovered by filtration, washed with water and dried. Recrystallization from DMF gave 1.0 g of 2-chloro-8-fluoro-9-oxo-9H-xanthene-3-yloxyacetic acid. m.p. 239°-242° C. This compound gave a mass spectrum having a molecular ion peak at m/e 322.

Provenance & Evidence