Hydrochloric Acid → HCID 13669834, compound

Participants

Reaction Steps

A mixture of 2.6 g of 3-chloro-8-fluoro-2-hydroxy-9-oxo-9H-xanthene, 3.4 g of potassium carbonate, 4.2 g of ethyl bromoacetate and 60 ml of DMF was stirred at 60°-65° C. for 5 hours. After cooling the mixture, 4 g of sodium hydroxide and 100 ml of water were added and the resulting mixture was stirred at 90°-100° C. for 30 minutes. After cooling, the mixture was rendered acidic with hydrochloric acid and the solid crystal was recovered by filtration, washed with water and dried. Recrystallization from ethanol gave 1.2 g of 3-chloro-8-fluoro-9-oxo-9H-xanthene-2-yloxyacetic acid. m.p. 242°-245° C. This compound exhibited a mass spectrum having a molecular ion peak at m/e 322.

Provenance & Evidence