反应详情

Ethyl 2-(2-aminothiazol-4-yl)-(Z)-2 -cyclopropylmethoxyiminoacetate (1.12 g) was suspended in ethanol (9 ml) and sodium hydroxide (1N; 9 ml) added. The mixture was stirred at room temerature for 40 h, acidified to pH2.8 and the ethanol removed. The precipitated solid was filtered off, washed with a little cold water, and dried in vacuo to give a white solid (845 mg) νmax (Nujol) 3350, 1640 br, and 1580 cm-1 ; δH [(CD3)2SO] inter alia 3.92 (2H, d, J 7 Hz), 6.82 (1H, s), and 7.20 (3H, very broad s, excn. D2O).

1. customthe ethanol removed
2. filtrationThe precipitated solid was filtered off
3. washwashed with a little cold water
4. customdried in vacuo