Sodium Hydroxide → HCID 14865043, compound

HRID 1194872Notes

Reaction equation

HRID 1194872 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:13]/[O:14][CH2:15][CH:16]2[CH2:18][CH2:17]2)/[C:8]([O:10]CC)=[O:9])[N:6]=1.[OH-].[Na+]>C(O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:13]/[O:14][CH2:15][CH:16]2[CH2:18][CH2:17]2)/[C:8]([OH:10])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14865027HCID 14865027, compound

Product 1

HCID 14865043HCID 14865043, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-(2-aminothiazol-4-yl)-(Z)-2 -cyclopropylmethoxyiminoacetate (1.12 g) was suspended in ethanol (9 ml) and sodium hydroxide (1N; 9 ml) added. The mixture was stirred at room temerature for 40 h, acidified to pH2.8 and the ethanol removed. The precipitated solid was filtered off, washed with a little cold water, and dried in vacuo to give a white solid (845 mg) νmax (Nujol) 3350, 1640 br, and 1580 cm-1 ; δH [(CD3)2SO] inter alia 3.92 (2H, d, J 7 Hz), 6.82 (1H, s), and 7.20 (3H, very broad s, excn. D2O).

Workup

  1. customthe ethanol removed
  2. filtrationThe precipitated solid was filtered off
  3. washwashed with a little cold water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-1e98e76fa9174f9da7938b98197cb19f
Source dataset
uspto-grants-1989_03
Patent number
US04816452

Reaction notes

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