1-Bromo-1-methylcyclohexane → ethyl (2Z)-2-(1-methylcyclopentyl)oxyimino-3-oxobutanoate

Participants

Reaction Steps

Ethyl (Z)-2-(hydroxyimino)-3-oxobutyrate (5.86 g, 36.8 mmol), 1-bromo-1-methylcyclohexane (6.01 g 36.8 mmol), and silver trifluoromethanesulphonate (9.45 g, 36.8 mmol) were reacted together by a similar method to that described in Example 9a to give the title compound (4.45 g, 50%); νmax (film) 2970, 1745, 1690, 1590, 1370, 1320, 1230, 1070, and 990 cm-1 ; δH (60 MHz, CDCl3), 1.31 (3H, t, J 7 Hz), 1.48 (3H, s), 1.1-2.2 (8H, m), 2.35 (3H, s), and 4.30 (2H, q, J 7 Hz).

Provenance & Evidence