Bromine → ethyl (2Z)-4-bromo-2-[(1R,2S)-2-methylcyclohexyl]oxyimino-3-oxobutanoate

Participants

Reaction Steps

Ethyl (Z)-2-(cis-2-methylcyclohexyloxyimino)-3-oxobutyrate (0.46 g) was treated with bromine as described in Example 4c to give the title compound (0.41 g, 68%), νmax (film) 2930, 1740, and 1695 cm-1, δH (CDCl3) 0.95 (3H, d, J 6.7 Hz), 1.35 (3H, t), 1.3-2.1 (9H, m), 4.35 (2H, s), 4.38 (2H, q), and 4.40 (1H, m). [Mass spectrum: +ve ion (ammonia) MH+ (334)].

Provenance & Evidence