HCID 178472882, compound → HCID 178472883, compound

HRID 1194927Notes

Reaction equation

HRID 1194927 reaction equation
C([NH:20][C:21]1[S:22][CH:23]=[C:24](/[C:26](=[N:32]/[O:33][C@H:34]2[CH2:39][CH2:38][C@@H:37]([Cl:40])[CH2:36][CH2:35]2)/[C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:25]=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(O)=O>[NH2:20][C:21]1[S:22][CH:23]=[C:24](/[C:26](=[N:32]/[O:33][C@H:34]2[CH2:35][CH2:36][C@@H:37]([Cl:40])[CH2:38][CH2:39]2)/[C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:25]=1

Participants

3

Reactant 1

HCID 178472882HCID 178472882, compound

Product 1

HCID 178472883HCID 178472883, compoundYield 68.4%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(cis-4-chlorocyclohexyloxyimino)acetate (205 mg) was deprotected using formic acid as described in Example 1a. After chromatography the crystalline title compound (81 mg) was obtained, having identical m.p. and spectroscopic data to Example 53c.

Sources & evidence

ORD record
ord-b111844804ad46568c9ed76ac84fe26b
Source dataset
uspto-grants-1989_03
Patent number
US04816452

Reaction notes

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