Hydrochloric Acid → HCID 178512879, compound

Participants

Reaction Steps

Into 5.2 ml (10.4 mmoles) of 2N HCl/AcOH was dissolved 2.3 g (2.6 mmoles) of Z-D-Orn(BOC)-Phe-Arg-CHA.HCl. After reacting it at room temperature for 2 hours, the product was precipitated in dry ether and the deposited crystalline product was collected by filtration and dried. Thus, crude Z-D-Orn-Phe-Arg-CHA.2HCl was obtained. It was purified by means of Toyopearl HW40F column with 30% AcOH as a developing solvent. Thus, 1.52 g (74.9%) of Z-D-Orn-Phe-Arg-CHA.2HCl was obtained.

Provenance & Evidence