Hydrochloric Acid → HCID 178427480, compound

Participants

Reaction Steps

Into 1.7 ml (3.5 mmoles) of 2N HCl/AcOH was dissolved 0.77 g (0.88 mmoles) of Tos-D-Lys(BOC)-Phe-Arg-CHA.HCl. After reacting it at room temperature for 2 hours, the reaction mixture was reprecipitated in dry ether and the deposited crystalline product was collected by filtration and dried. Thus, 0.70 g of crude Tos-D-Lys-Phe-Arg-CHA.2HCl was obtained. It was purified by means of Toyopearl HW40F column with 30% AcOH as a developing solvent. Thus, 0.48 g (67.6%) of Tos-D-Lys-Phe-Arg-CHA.2HCl was obtained.

Provenance & Evidence