Dimethylformamide → HCID 70380161, compound

Participants

Reaction Steps

14.1 g (67.1 mmol) of rac-(Z)-4-[(p-methoxyphenyl)thio]-3-buten-2-ol in 250 ml of of methylene chloride and 25 ml of N,N-dimethylformamide are treated with 15.2 g (100 mmol) of t-butyldimethylchlorosilane and 13.6 g (18.7 ml) of triethylamine, the reaction mixture is stirred at room temperature for 6 hours and evaporated. The oil obtained is taken up in 500 ml of ether, washed three times with 100 ml of water each time, dried over sodium sulphate and filtered through silica gel. There is obtained 4-[[(Z)-3-(t-butyldimethylsilyloxy)-1-butenyl]thio]anisole.

Provenance & Evidence