Ethyl 2-(bromomethyl)benzoate → Ethyl 4-(2-ethoxycarbonylbenzyloxy)-alpha-methylphenylacetate

HRID 1195024Notes

Reaction equation

HRID 1195024 reaction equation
[CH3:1][CH:2]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].Br[CH2:16][C:17]1[C:18]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=1>>[CH2:26]([O:25][C:23]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][O:14][C:11]1[CH:10]=[CH:9][C:8]([CH:2]([CH3:1])[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[CH:13][CH:12]=1)=[O:24])[CH3:27]

Participants

3

Reactant 2

HCID 11032082Ethyl 2-(bromomethyl)benzoateHCID 12785115Ethyl 2-(4-hydroxyphenyl)propanoate

Product 1

HCID 54555132Ethyl 4-(2-ethoxycarbonylbenzyloxy)-alpha-methylphenylacetate

Procedure

Reaction of ethyl α-methyl-p-hydroxyphenylacetate with ethyl α-bromo-o-toluate by the method described in Example 1b provides ethyl 4-(2-ethoxycarbonylbenzyloxy)-α-methylphenylacetate as a clear oil.

Sources & evidence

ORD record
ord-5b9f9d3664864c85a91f6ce9a3c75a8f
Source dataset
uspto-grants-1989_03
Patent number
US04816591

Reaction notes

Loading…