Ethyl 2-(bromomethyl)benzoate → Ethyl 4-(2-ethoxycarbonylbenzyloxy)-alpha,alpha-dimethylphenylacetate

HRID 1195026Notes

Reaction equation

HRID 1195026 reaction equation
[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Br[CH2:17][C:18]1[C:19]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:20][CH:21]=[CH:22][CH:23]=1>>[CH2:27]([O:26][C:24]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:17][O:15][C:12]1[CH:11]=[CH:10][C:9]([C:2]([CH3:1])([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[CH:14][CH:13]=1)=[O:25])[CH3:28]

Participants

3

Reactant 2

HCID 11032082Ethyl 2-(bromomethyl)benzoateHCID 21269145Ethyl 2-(4-hydroxyphenyl)-2-methylpropanoate

Product 1

HCID 21269141Ethyl 4-(2-ethoxycarbonylbenzyloxy)-alpha,alpha-dimethylphenylacetate

Procedure

Reaction of ethyl α,α-dimethyl-p-hydroxyphenylacetate with ethyl α-bromo-o-toluate as described in Example 1b provides ethyl 4-(2-ethoxycarbonylbenzyloxy)-α,α-dimethylphenylacetate.

Sources & evidence

ORD record
ord-c79fb5bb8c90471b8d1a3158ea805a1f
Source dataset
uspto-grants-1989_03
Patent number
US04816591

Reaction notes

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