Potassium Hydroxide → 4-(2-Carboxybenzyloxy)-alpha,alpha-dimethylphenylacetic acid

HRID 1195027Notes

Reaction equation

C([O:3][C:4]([C:6]1[CH:27]=[CH:26][CH:25]=[CH:24][C:7]=1[CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([CH3:23])([CH3:22])[C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=1)=[O:5])C.[OH-].[K+]>>[C:4]([C:6]1[CH:27]=[CH:26][CH:25]=[CH:24][C:7]=1[CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([CH3:22])([CH3:23])[C:17]([OH:19])=[O:18])=[CH:12][CH:11]=1)([OH:5])=[O:3]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 21269141Ethyl 4-(2-ethoxycarbonylbenzyloxy)-alpha,alpha-dimethylphenylacetate

Product 1

HCID 212691494-(2-Carboxybenzyloxy)-alpha,alpha-dimethylphenylacetic acid

Procedure

Reaction of ethyl 4-(2-ethoxycarbonylbenzyloxy)-α,α-dimethylphenylacetate with potassium hydroxide as described in Example 1c provides 4-(2-carboxybenzyloxy)-α,α-dimethylphenylacetic acid.

Sources & evidence

ORD record: ord-854d77cd89a84bba973f8f3ffd9137a1
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04816591

Reaction notes

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