Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Isoxepac | HCID 41448 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 12446847 | HCID 12446847 | — |
Reaction Steps
A solution of 5.0 g. of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid in 16 ml. of 5% sodium hydroxide is added dropwise to a cold solution of 1.36 g. of sodium borohydride in 40 ml. of water. The reaction mixture is stirred at 0° C. for 4 hours, poured onto ice, and acidified with glacial acetic acid. The precipitate is filtered and washed with water to provide colorless crystals, m.p. 132°-133.5° C. of 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04816591 |
|---|
| Source dataset | uspto-grants-1989_03 |
|---|
| ORD ID | ord-d62ff11ffd8049bdae4ce7fea803e36d |
|---|
| Source note | uspto-grants-1989_03 |
|---|
