Sodium Iodide → HCID 88629896, compound

Participants

Reaction Steps

80.55 g of ethyl 2-(2-amino-4-thiazolyl)-2-[(Z)-(2-bromoethoxy)imino]-acetate and 187.4 g of sodium iodide are boiled under reflux in 1.5 l of methyl ethyl ketone for 1.5 hours. After removal of the solvent by evaporation, the residue is partitioned between 0.6 l of water and 0.2 l of ethyl acetate, the aqueous phase is back-extracted twice with 0.2 l of ethyl acetate each time, the organic extracts are thereupon combined, washed with 0.2 l of aqueous 15% sodium chloride solution, dried and evaporated. The residue is recrystallized from 0.7 l of toluene. 83.5 g of ethyl 2-(2-amino-4-thiazolyl)-2-[(Z)-(2-iodoethoxy)imino]acetate are obtained.

Provenance & Evidence