Water → HCID 21269061, compound

Participants

Reaction Steps

8.1 g of ethyl 2-(2-amino-4-thiazolyl)-2-[(Z)-(2-azidoethoxy)imino]-acetate are dissolved in 150 ml of methanol and 45 ml of 2N aqueous sodium hydroxide solution. After 20 hours, 50 ml of water are added thereto. The methanol is then removed in vacuo. The aqueous solution is treated with 90 ml of 1N aqueous hydrochloric acid and concentrated to dryness. The residue is taken up in 200 ml of dimethylformamide. The sodium chloride is removed by filtration and the solution is concentrated to 50 ml. The acid is precipitated by the addition of acetonitrile. There are obtained 6.5 g of 2-(2-amino-4-thiazolyl)-2-[(Z)-(2-azidoethoxy)imino]-acetic acid. Yield: 6.5 g of melting point 180° C.

Provenance & Evidence