HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → HCID 67869033, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Nicergoline | HCID 34040 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 67869033 | HCID 67869033 | — |
Reaction Steps
Following the process of Example 25, 1 g of nicergoline (8-[(5-bromonicotinoyl)oxymethyl]-1,6-dimethyl-10-methoxyergoline) is reacted with 1.6 ml of trimethylchlorosilane and the obtained product is isolated by chromatography on a Kieselgel column, using a 7:3 mixture of benzene and acetone as eluant, to give the title compound in a yield of 0.65 g (0.00125 mole, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04816587 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-aef1c6e739314dd1b64d16d1d14a000e |
| Source note | uspto-grants-1989_03 |