Bromotrimethylsilane → HCID 13059865, compound

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Reaction Steps

Following the process of Example 25, 1 g of lysergic acid methyl ester is reacted with 2.7 ml of trimethylbromosilane and the product is purified by chromatography on a Kieselgel column by using a 7:3 mixture of benzene and acetone as eluant. After recrystallization from benzene, the title compound is obtained in a yield of 0.7 g (0.0019 mole, 55%), m.p.: 177°-178° C., [α]D20 =+41° (c=1, chloroform).

Provenance & Evidence