HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromotrimethylsilane → Bromocriptine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | 55852-82-9 | HCID 12309776 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Bromocriptine | HCID 31101 | — |
Reaction Steps
Following the process of Example 30, 1 g of α-ergocryptine phosphate is brominated with 2.0 ml of trimethylbromosilane. After isolating, the title base is obtained in a yield of 0.9 g (0.001359 mole, 91.5%), m.p.: 218° C., [α]D20 =-195° (c=1, dichloromethane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04816587 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-fb7ea1fbb60f4e91b6c9cda98e4beac2 |
| Source note | uspto-grants-1989_03 |