Bromotrimethylsilane → Bromocriptine

Participants

Reaction Steps

Following the process of Example 33, 10 g of a mixture of α-ergocryptine phosphate and ergosine phosphate (containing 48.9% of α-ergocryptine base, 1.9% of α-ergocryptinine base, 28.2% of ergosine base and 1.3% of ergosinine base) is brominated with 20 ml of trimethylbromosilane and the title compound is isolated in a yield of 4.7 g (0.007243 mole, 85%), m.p.: 218° C. [α]D20 =-195° (c=1, dichloromethane).

Provenance & Evidence