HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → HCID 131717330, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 2-Aminobenzonitrile | HCID 72913 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 131717330 | HCID 131717330 | — |
Reaction Steps
2-cyanoaniline (59g), ethyl bromoacetate (90g) and sodium bicarbonate (50g) were refluxed in ethanol (500ml), with stirring, for 42 hours. The reaction mixture was cooled slightly, filtered, and the filtrate cooled. The solid which formed was removed by filtration. Evaporation left an oil, containing unreacted starting material and the desired product, N-(2-cyanophenyl) glycine, ethyl ester. Trituration with ethanol and cooling gave the required product which after filtering was crystallized from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05110348 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-71336d76c028434d8ff063323ddb19f0 |
| Source note | uspto-grants-1992_05 |