Hydrochloric Acid → 4-(5-Decylpyrimidin-2-yl)benzoic acid

Participants

Reaction Steps

5-n-Decyl-2-(4'-cyanophenyl)pyrimidine (2.0 g) was refluxed together with diethyl glycol (15 ml) and potassium hydroxide (1.0 g) for 1 day. The reaction mixture was poured in a mixed solution of water (100 ml) and concentrated hydrochloric acid (50 ml) and the mixture was stirred for half a day under heating. The precipitated crystal was collected and washed with water and then recrystallized from ethanol to obtain the titled compound (2.0 g).

Provenance & Evidence