Thionyl Chloride → HCID 53714778, compound

HRID 1195114Notes

Reaction equation

HRID 1195114 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[N:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[CH:13][N:12]=1)[C:5](O)=[O:6].S(Cl)([Cl:27])=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[N:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[CH:13][N:12]=1)[C:5]([Cl:27])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 53684102HCID 53684102, compound

Product 1

HCID 53714778HCID 53714778, compound

Procedure

3-Fluoro-4-(5-n-octylpyrimidine-2-yl)benzoic acid (1.66 g) was heated together with excess thionyl chloride for 8 hours under reflux and thereafter, unaltered thionyl chloride was distilled off to obtain 3-fluoro-4-(5-n-octylpyrimidine-2-yl)benzoic acid chloride.

Workup

  1. temperatureunder reflux
  2. distillationunaltered thionyl chloride was distilled off

Sources & evidence

ORD record
ord-4d69752386fc47389edb5001cf11a021
Source dataset
uspto-grants-1992_05
Patent number
US05110496

Reaction notes

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