Benzyl Alcohol → HCID 178525875, compound

Participants

Reaction Steps

A mixture of 2.2 g of Nα -t-butoxycarbonyl-Nim -2,4-dinitrophenyl-L-histidine monohydrate, 0.62 ml of benzyl alcohol, 1.03 g of N,N'-dicyclohexylcarbodiimide and 1.53 g of 1-hydroxybenzotriazole in 20 ml of methylene chloride was stirred overnight at ambient temperature. The mixture was then filtered and the solid rinsed with methylene chloride. The filtrates were combined and concentrated under vacuum. Chromatography of the residue over silica gel (gradient 1% to 2% methanol in methylene chloride) provided 1.76 g of the title compound.

Provenance & Evidence