HCID 131717332, compound → HCID 131717331, compound

HRID 1195137Notes

Reaction equation

HRID 1195137 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:31]([O:33]CC1C=CC=CC=1)=[O:32])[CH2:3][CH2:4][C:5]([NH:7][C@H:8]([C:16]([NH:18][CH2:19][CH2:20][C:21]([O:23]CC1C=CC=CC=1)=[O:22])=[O:17])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:6]>[Pd]>[NH2:1][C@H:2]([C:31]([OH:33])=[O:32])[CH2:3][CH2:4][C:5]([NH:7][C@H:8]([C:16]([NH:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[O:17])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:6]

Participants

3

Reactant 1

HCID 131717332HCID 131717332, compound

Product 1

HCID 131717331HCID 131717331, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In the same manner as Example 6 (iv), 2.50 g of Z-Glu(Phe-β-Ala-OBzl)-OBzl was hydrogenated in the presence of Pd-C and removed the protecting group to give 1.30 g of γ-Glu-Phe-β-Ala (Compound 33); yield 99%.

Workup

  1. customremoved the protecting group

Sources & evidence

ORD record
ord-b5d19cd52439400081f282b5691fdd9e
Source dataset
uspto-grants-1992_05
Patent number
US05110797

Reaction notes

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