反应详情

A mixture of 6.11 g 5-[5-(2,6-dichloro-4-cyanophenoxy)pentyl]-3-methylisoxazole (m.p. 59°-60° C.), 75 ml 35% sodium hydroxide and 75 ml ethanol was stirred on a steam bath for several hours. The reaction mixture upon standing separated into a clear lower layer and a yellow upper layer. The latter was separated, diluted with cold water and acidified with hydrochloric acid. The resulting solid was collected and recrystallized from acetonitrile to give 5.24 g 3,5-dichloro-4-[5-(3-methylisoxazol-5-yl)pentyloxy]benzoic acid, m.p. 67°-69° C.

1. customThe reaction mixture upon standing separated into a clear lower layer
2. customThe latter was separated
3. additiondiluted with cold water
4. customThe resulting solid was collected
5. customrecrystallized from acetonitrile