Tetrafluoroboric acid → 9-(2,3,5-Tri-O-benzyl-beta-D-arabinofuranosyl)-2-fluoroadenine

Participants

Reaction Steps

The process of claim 1 wherein in addition the 2-amino group of (V) is replaced with a 2-fluoro group by reaction with fluoroboric acid in an organic solvent for the reaction to form 9-(2,3,5 tri-O-benzyl-beta-D-arabinofuranosyl)-2-fluoroadenine (VI) and wherein (VI) is treated in a reaction mixture with hydrogen and palladium chloride in an organic solvent and in a sealed vessel under pressure to produce 9-beta-D-arabinofuranosyl-2-fluoroadenine (VII) which is separated from the reaction mixture.

Provenance & Evidence