Acetic Acid → HCID 19001632, compound

HRID 1195279Notes

Reaction equation

HRID 1195279 reaction equation
C([O:8][CH2:9][CH2:10][C:11]1[C:19]([CH3:20])=[CH:18][C:14]2[O:15][CH2:16][O:17][C:13]=2[CH:12]=1)C1C=CC=CC=1.C(O)(=O)C>C(O)C.[Pd]>[CH3:20][C:19]1[C:11]([CH2:10][CH2:9][OH:8])=[CH:12][C:13]2[O:17][CH2:16][O:15][C:14]=2[CH:18]=1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 19001663HCID 19001663, compound

Product 1

HCID 19001632HCID 19001632, compoundYield 79%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1.9 g of 5-(2-benzyloxyethyl)-6-methyl-1,3-benzodioxole was dissolved in 80 ml of ethanol. 0.2 g of 10% palladium/carbon (containing 50% water) and 4 ml of acetic acid were added thereto and the catalytic reduction was conducted under 3 atm/cm2 for 1 h. After removing palladium/carbon, ethanol was distilled off and the product was purified according to silica gel column chromatography (ethyl acetate/hexane=2:3) to obtain 1.0 g of the intended compound in the form of a faint yellow oil.

Workup

  1. customAfter removing palladium/carbon, ethanol
  2. distillationwas distilled off
  3. customthe product was purified

Sources & evidence

ORD record
ord-4960806887c84a7f86c76f20295169e9
Source dataset
uspto-grants-1992_05
Patent number
US05110956

Reaction notes

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