Benzene → HCID 53904180, compound

HRID 1195364Notes

Reaction equation

HRID 1195364 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)=[C:9]([C:12]2[N:16]([CH3:17])[N:15]=[N:14][N:13]=2)C=O)=[CH:4][CH:3]=1.C1(P(=[CH:44][CH:45]=[O:46])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH:47]1C=CC=CC=1>>[F:24][C:21]1[CH:22]=[CH:23][C:18]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[C:9]([C:12]2[N:16]([CH3:17])[N:15]=[N:14][N:13]=2)[CH:47]=[CH:44][CH:45]=[O:46])=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 241BenzeneHCID 75051(Triphenylphosphoranylidene)acetaldehydeHCID 14539527HCID 14539527, compound

Product 1

HCID 53904180HCID 53904180, compound

Procedure

A solution of 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)propenal (1.0 g, 3.07 mmoles) and triphenylphosphoranylidene acetaldehyde (0.93 g, 3.07 mmoles) in benzene was heated at reflux for 1 hour. The benzene was removed in vacuo and the residue was purified by column chromatography on silica gel eluting with 15% (v/v) ethyl acetate in hexane to give 0.7 g of the title compound; m.p.=156°-157.5° C.

Workup

  1. temperatureat reflux for 1 hour
  2. customThe benzene was removed in vacuo
  3. customthe residue was purified by column chromatography on silica gel eluting with 15% (v/v) ethyl acetate in hexane

Sources & evidence

ORD record
ord-d200bb0f391249218eccdee2e989c486
Source dataset
uspto-grants-1992_05
Patent number
US05110940

Reaction notes

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