Sodium Hydroxide → HCID 86745756, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the dihydroxyester prepared in Step D (35 mg; 0.068 mmole) in ethanol (2 mL) was treated with 1N NaOH solution (68 l; 0.068 mmole) and the mixture stirred for 30 minutes at 23° C. The solvent was removed by evaporation in vacuo and the residue dissolved in water (2 mL) and lyophilized to afford 36 mg (100%) of the title compound; m.p.>110° C. decomp. [α]D25 =-22.2° (c=0.32, H2O). The 1H NMR and 13C NMR are identical to the (±)-erythro product prepared in Example 12.

Provenance & Evidence