HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+)-L-Leucine methyl ester → HCID 54265930, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+)-L-Leucine methyl ester | HCID 65105 | — |
| Reactant | 2H-Pyran-2-one, 6-((1E)-4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadien-1-yl)tetrahydro-4-hydroxy-, (4R,6S)-rel- | HCID 9932838 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54265930 | HCID 54265930 | — |
Reaction Steps
When a solution of trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one in tetrahydrofuran is treated with at least one equivalent of L-leucine methyl ester (prepared in situ from the hydrochloride salt) and heated to reflux temperature, the title compound is thereby produced. EXAMPLE 148
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05110940 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-6453b3db2abf4735a3f2b365e26d0a3a |
| Source note | uspto-grants-1992_05 |