Sodium Hydroxide → HCID 54454780, compound

HRID 1195404Notes

Reaction equation

HRID 1195404 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=2)=[C:9]([C:30]2[N:34]([CH3:35])[N:33]=[N:32][N:31]=2)[CH:10]=[CH:11][C@@H:12]([OH:29])[CH2:13][C@@H:14]([OH:28])[CH2:15][C:16]([NH:18][C@H:19]([C:24]([O:26]C)=[O:25])[CH2:20][CH:21]([CH3:23])[CH3:22])=[O:17])=[CH:4][CH:3]=1.[OH-].[Na+]>O1CCOCC1.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=2)=[C:9]([C:30]2[N:34]([CH3:35])[N:33]=[N:32][N:31]=2)[CH:10]=[CH:11][C@@H:12]([OH:29])[CH2:13][C@@H:14]([OH:28])[CH2:15][C:16]([NH:18][C@H:19]([C:24]([OH:26])=[O:25])[CH2:20][CH:21]([CH3:23])[CH3:22])=[O:17])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54265930HCID 54265930, compound

Product 1

HCID 54454780HCID 54454780, compound

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

When a solution of the compound from Example 147 in dioxane-water is treated at a temperature of about 0° C. with 1N NaOH and then acidified after workup, the title compound is thereby produced.

Sources & evidence

ORD record
ord-e0fb51cc677f42568aaeb2d8717523d2
Source dataset
uspto-grants-1992_05
Patent number
US05110940

Reaction notes

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