Potassium Carbonate → HCID 53813730, compound

Participants

Reaction Steps

3.31 g (16.8 mmol) of 2-chloro-6-(N,N-dimethylamino)-9H-purine are dissolved in 60 ml of N,N-dimethylformamide. 4.16 g (30.2 mmol) of potassium carbonate and 2.02 ml (16.8 mmol) of 2-fluorobenzyl bromide are added to the solution. The reaction mixture is then stirred for 3 hours at room temperature and then ice water is added and the whole is extracted three times with dichloromethane. The combined organic phases are washed twice with water, dried over magnesium sulfate and concentrated by evaporation. The residue is chromatographed on silica gel with toluene/ethyl acetate (3:1) as eluant. The eluate is concentrated by evaporation and the residue obtained is recrystallised from ethyl acetate/diethyl ether. In this manner 2-chloro-6-(N,N-dimethylamino)-9-(2-fluorobenzyl)-9H-purine is obtained in the form of colourless needles having a melting range of from 130° to 131°.

Provenance & Evidence