Dimethylamine → HCID 54049040, compound

HRID 1195437Notes

Reaction equation

HRID 1195437 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[CH:4][N:3]=1.[CH3:19][NH:20][CH3:21]>>[CH3:19][N:20]([C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[CH:4][N:3]=1)[CH3:21]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 24904076HCID 24904076, compound

Product 1

HCID 54049040HCID 54049040, compound

Procedure

In a manner analogous to that described in Example 2 it is also possible, by reacting 2-chloro-9-(2-fluorobenzyl)-9H-purine (Example 7) with N,N-dimethylamine, to obtain the 2-(N,N-dimethylamino)-9-(2-fluorobenzyl)-9H-purine, which has a melting range of from 112° to 113° (methanol/diethyl ether), the reaction mixture being heated for 24 hours at from 80° to 85°.

Sources & evidence

ORD record
ord-461936173f4e4aabb603f7076f6497b4
Source dataset
uspto-grants-1992_05
Patent number
US05110818

Reaction notes

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