Ammonia → HCID 53844988, compound

HRID 1195438Notes

Reaction equation

HRID 1195438 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[C:4]([NH:19][CH3:20])[N:3]=1.[NH3:21]>>[NH2:21][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[C:4]([NH:19][CH3:20])[N:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 54513967HCID 54513967, compound

Product 1

HCID 53844988HCID 53844988, compound

Procedure

In a manner analogous to that described in Example 2 it is also possible, by reacting 2-chloro-9-(2-fluorobenzyl)-6-(N-methylamino)-9H-purine (Example 6) with ammonia, to obtain the 2-amino-9-(2-fluorobenzyl)-6-(N-methylamino)-9H-purine, which has a melting range of from 207° to 208°.

Sources & evidence

ORD record
ord-191335f7448543efbeee2324bbf12749
Source dataset
uspto-grants-1992_05
Patent number
US05110818

Reaction notes

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