2-Chlorobenzyl chloride → HCID 54051665, compound

HRID 1195439Notes

Reaction equation

HRID 1195439 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([NH:11][CH3:12])[N:3]=1.[Cl:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16]Cl>>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[Cl:13])=[C:4]([NH:11][CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 119062-Chlorobenzyl chlorideHCID 178482383HCID 178482383, compound

Product 1

HCID 54051665HCID 54051665, compound

Procedure

In a manner analogous to that described in Example 17 it is possible, by reacting 2-chloro-6-(N-methylamino)-9H-purine (Example 6) with 2-chlorobenzyl chloride, to obtain the 2-chloro-9-(2-chlorobenzyl)-6-(N-methylamino)-9H-purine, which melts at from 203° to 204° (N,N-dimethylformamide/diethyl ether).

Sources & evidence

ORD record
ord-128d74f563ed4e08b9263738d13ad49a
Source dataset
uspto-grants-1992_05
Patent number
US05110818

Reaction notes

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