HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → 2H-Pyran, tetrahydro-2-[(3-methyl-3-butenyl)oxy]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 71353452 | HCID 71353452 | — |
| Catalyst | Methanesulfonic Acid | HCID 6395 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2H-Pyran, tetrahydro-2-[(3-methyl-3-butenyl)oxy]- | HCID 12290655 | 100.5% |
Reaction Steps
To isoprenyl alcohol (80.0 g, 929 mmol) in CH2Cl2 (500 ml) at 0° C. was added one drop of methanesulfonic acid. To this solution was added 2,3-dihydropyran (100 ml, 1.10 mol) dropwise over 3 h. After the addition was complete triethylamine (5 ml) was added and the resulting mixture was filtered through a thin pad of SiO2 and concentrated to afford 159 g (100%) of 2-(3-methyl-3-butenyloxy)tetrahydropyran as a colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112595 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-d0beb8aeaabb4b1095ae2b8dbb94e40e |
| Source note | uspto-grants-1992_05 |