1-Chloro-3-methoxypropane → Bis(3-methoxypropyl)methylphosphine

Participants

Reaction Steps

3-Methoxypropyl-magnesium chloride was generated from 1 -chloro-3-methoxypropane (10.0 g, 92.0 mmol) and Mg metal (2.26 g, 93.0 mmol) and reacted with dichloromethylphosphine (4.1 ml, 0.46 mmol) according to General Method I. The residue was purified by fractional distillation (bp=110° [email protected] mm Hg) affording 5.9 g (68%) of bis(3-methoxypropyl)methylphosphine as a mobile colorless oil. 31PNMR(Benzene-d6):δ -43.3. MS (HREI) m/z=192.1279 (192.1279 calc'd for C9H21O2P).

Provenance & Evidence