Ethanol → HCID 53989226, compound

HRID 1195643Notes

Reaction equation

HRID 1195643 reaction equation
C([O:4][CH2:5][C:6]([CH2:21][O:22]C(=O)C)([C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([S:17]([NH2:20])(=[O:19])=[O:18])=[CH:13][CH:12]=1)=[O:9])[CH3:7])(=O)C.[OH-].[Na+].C(O)C>O>[OH:4][CH2:5][C:6]([CH2:21][OH:22])([C:8]([NH:10][C:11]1[CH:12]=[CH:13][C:14]([S:17]([NH2:20])(=[O:18])=[O:19])=[CH:15][CH:16]=1)=[O:9])[CH3:7]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 54309401HCID 54309401, compound

Product 1

HCID 53989226HCID 53989226, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Then, 22 g (0.06 mole) of p-(1,1-bis(acetoxymethyl)ethylcarbonylamino)benzenesulfonamide, 4.8 g (0.12 mole) of sodium hydroxide, 50 ml of ethanol and 50 ml of water were introduced into a 300 ml three-necked flask equipped with a stirring machine and a condenser and refluxed while heating for 2 hours. The reaction mixture was poured into 1 l of water while stirring, then stirred for 30 minutes and filtered to give white solid of p-(1,1-bis(hydroxymethyl)ethylcarbonylamino)benzenesulfonamide. The white solid was purified by recrystallization from ethanol (yield 11 g).

Workup

  1. customequipped with a stirring machine and a condenser
  2. temperaturerefluxed
  3. temperaturewhile heating for 2 hours
  4. stirringstirred for 30 minutes
  5. filtrationfiltered

Sources & evidence

ORD record
ord-fbc2fd10d34044caab3980c1d102f47f
Source dataset
uspto-grants-1992_05
Patent number
US05112743

Reaction notes

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