HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 15166991, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | HCID 86744866 | HCID 86744866 | — |
| Solvent | Diisopropylethylamine | HCID 81531 | — |
| Product | HCID 15166991 | HCID 15166991 | — |
Reaction Steps
Methyl 4(lH)-thioquinolone-2-carboxylate (1.0 equivalent) from example 24 is suspended/dissolved in MeOH containing a catalytic amount of ethyldiisopropylamine. To this mixture is added methyl acrylate (3 equivalent) and the whole is refluxed for 3 hours. The bulk of the solvent is removed under vacuum and the residue is recrystallized from ethyl acetate/ hexane to give methyl 4-(2-methoxycarbonyl-ethylthio)-quinoline-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112821 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-9298245b37bb4055a4e03d1b035203e6 |
| Source note | uspto-grants-1992_05 |