Hydrochloric Acid → HCID 86745769, compound

Participants

Reaction Steps

To a solution of trans-N,N-dimethyl-2-[(2S,4S)-4-acetylthio -N-(4-nitrobenzyloxycarbonyl)pyrrolidin-2-yl]cyclopropanecarboxamide (220 mg, 0.5 mmol) in methanol (11 ml) was added 2N sodium hydroxide solution(0.50 ml, 1.0 mmol) under ice-cooling, and the solution stirred for 1 hour. To the reaction mixture was added 6N hydrochloric acid (0.17 ml, 1.0 mmol), and the mixture poured into water (10 ml) and extracted with methylene chloride (20 ml×2). The organic layer was dried (MgSO4) and evaporated in reduced pressure to give a residue of trans-N,N-dimethyl-2-[(2S,4S)-4-mercapto-N-(4-nitrobenzyloxycarbonyl) pyrrolidin-2-yl]cyclopropanecarboxamide. ##STR170##

Provenance & Evidence