Hydrochloric Acid → HCID 56977651, compound

Participants

Reaction Steps

A stirred solution of ethyl trans-2-[(2S, 4R)-4-methanesulfonyloxy-N-(4-nitrobenzyloxycarbonyl) pyrrolidin-2-yl]cyclopropanecarboxylate (750 mg, 1.64 mmol) and MeOH (15 ml) was treated with 2N LiOH (2.4 ml, 4.8 mmol) at room temperature over 12 hours. The reaction mixture was neutralized with 6N HCl (0.80 ml, 4.8 mmol) and extracted with CH2Cl2 (20 ml×2). The organic layers were combined, dried (MgSO4) and concentrated to afford trans-2-[(2S, 4R)-4-methanesulfonyloxy-N-(4-nitrobenzyloxycarbonyl)pyrrolidin-2yl]cyclopropanecarboxylic acid (565 mg, 80% yield) as a residue.

Provenance & Evidence