Chloroform → HCID 54048185, compound

HRID 1195663Notes

Reaction equation

HRID 1195663 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[Na+].[Na+].ClC(Cl)Cl.Cl[C:24]([O:26][CH2:27][CH3:28])=[O:25]>O>[CH2:27]([O:26][C:24]([N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1)=[O:25])[CH3:28]

Participants

6

Reactant 4

HCID 6212ChloroformHCID 10340Sodium CarbonateHCID 10928Ethyl chloroformateHCID 2760465Ethyl 2-(piperidin-4-yl)acetate

Product 1

HCID 54048185HCID 54048185, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred mixture of 175.4 parts of ethyl 4-piperidineacetate, 116.6 parts of sodium carbonate and 2250 parts of trichloromethane were added dropwise 119.4 parts of ethyl chloroformate. After stirring for 4 hours at temperature, the reaction mixture was diluted with 400 parts of water. The organic layer was separated, dried, filtered and evaporated, yielding 277 parts (100%) of ethyl 1-(ethoxycarbonyl)-4-piperidineacetate (interm. 16).

Workup

  1. customThe organic layer was separated
  2. customdried
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-e039da255a5141aeaad6d620e0647462
Source dataset
uspto-grants-1992_05
Patent number
US05112825

Reaction notes

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