HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 5-(2-Piperazin-1-ylethyl)-2,1,3-benzoxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 5-[2-(Methanesulfonyloxy)ethyl]benzofurazan | HCID 15166381 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(2-Piperazin-1-ylethyl)-2,1,3-benzoxadiazole | HCID 15166382 | 97% |
Reaction Steps
5-[2-(Methanesulfonyloxy)ethyl]benzofurazan (242 mg, 1 mmol) and piperazine (0.86 g, 10 mmol) in DMF (9 ml) were stirred together at room temperature for 19 hours. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography on silica gel eluting with CH2Cl2 /CH3OH/NH3 (Aq.); 90:10:1 to give the piperazine as a yellow solid (225 mg, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112824 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-df5a5f5c60cd4465980c14eef44fa9bf |
| Source note | uspto-grants-1992_05 |