HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-(Methanesulfonyloxymethyl)benzofurazan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2,1,3-Benzoxadiazol-5-ylmethanol | HCID 2776297 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(Methanesulfonyloxymethyl)benzofurazan | HCID 19045251 | 99.7% |
Reaction Conditions
| Temperature | -20 °C |
|---|
Reaction Steps
5-Benzofurazanmethanol (0.6 g, 4 mmol) and triethylamine (0.84 mmol, 0.61 g, 6 mmol) were dissolved in dichloromethane (20 ml) and cooled to -20° C. Methanesulfonyl chloride (0.37 ml, 0.55 g, 4.8 mmol) was added dropwise and the mixture was stirred at -20° C. for 20 minutes, diluted with dichloromethane (30 ml), washed with water (30 ml), dried (Na2SO4), and evaporated under reduced pressure to give the benzofurazan as a white solid (0.91 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112824 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-e4cf4ba955264aa487a34d04efd49bbb |
| Source note | uspto-grants-1992_05 |