HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium iodide → 1-[2-(4-Nitrophenyl)ethyl]-4-(benzofurazan-5-carbonyl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium iodide | HCID 66321 | — |
| Reactant | 4-Nitrophenethyl bromide | HCID 79266 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-(Benzofurazan-5-carbonyl)piperidine hydrochloride | HCID 67916351 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[2-(4-Nitrophenyl)ethyl]-4-(benzofurazan-5-carbonyl)piperidine hydrochloride | HCID 67916437 | — |
Reaction Steps
In the manner described in Example 14, 4-(benzofurazan-5-carbonyl)piperidine hydrochloride (80 mg, 0.3 mmol), 4-nitrophenethyl bromide (172 mg, 0.75 mmol), sodium bicarbonate (101 mg, 1.2 mmol), and lithium iodide (1 mg) in ethanol (3 ml) under reflux for 3 hours gave, after purification by flash column chromatography on silica gel, eluting with CH2Cl2 /CH3OH/NH3 (Aq.); 96:4:0.4 and treatment with ethanolic HCl, the hydrochloride as a white solid (44 mg, 35%), mp 238°-240° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112824 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-4e2807ca03424b35a8fb56d0c54070f7 |
| Source note | uspto-grants-1992_05 |